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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN18
All Species:
5.76
Human Site:
T378
Identified Species:
14.07
UniProt:
Q99952
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99952
NP_055184.2
460
50482
T378
Q
T
G
T
G
T
G
T
G
A
R
S
A
E
E
Chimpanzee
Pan troglodytes
XP_513663
807
91678
F575
P
T
S
S
T
S
L
F
S
Y
Y
N
S
N
D
Rhesus Macaque
Macaca mulatta
XP_001093333
456
50339
S378
E
T
G
T
G
A
R
S
A
E
E
V
P
L
Y
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61152
453
50183
T378
R
A
P
T
S
T
D
T
P
I
Y
S
Q
V
A
Rat
Rattus norvegicus
NP_001013129
453
50088
T378
R
A
P
N
S
T
D
T
P
I
Y
S
Q
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521024
682
72925
S549
P
P
P
P
S
S
E
S
K
P
R
E
P
Q
Y
Chicken
Gallus gallus
XP_001235234
775
85980
F411
Q
K
H
R
S
L
Q
F
S
S
R
S
S
E
Q
Frog
Xenopus laevis
NP_001121240
511
57423
P394
T
V
E
Y
V
N
V
P
T
H
V
P
T
P
Q
Zebra Danio
Brachydanio rerio
NP_001013470
513
57261
K382
Y
D
N
A
N
S
E
K
T
N
N
S
A
V
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
L682
K
T
E
S
L
R
K
L
S
S
G
S
V
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.1
94.7
N.A.
N.A.
75.8
74.7
N.A.
36.5
27.6
42.2
39.1
N.A.
N.A.
N.A.
N.A.
22.6
Protein Similarity:
100
38.7
96.5
N.A.
N.A.
82.6
82.3
N.A.
46.9
40.6
58.7
55.3
N.A.
N.A.
N.A.
N.A.
32.4
P-Site Identity:
100
6.6
26.6
N.A.
N.A.
26.6
20
N.A.
6.6
26.6
0
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
40
40
N.A.
N.A.
33.3
26.6
N.A.
26.6
46.6
6.6
20
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
10
0
10
0
0
10
10
0
0
20
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
20
0
0
0
0
0
0
0
10
% D
% Glu:
10
0
20
0
0
0
20
0
0
10
10
10
0
20
10
% E
% Phe:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
% F
% Gly:
0
0
20
0
20
0
10
0
10
0
10
0
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% I
% Lys:
10
10
0
0
0
0
10
10
10
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
10
10
10
10
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
10
10
0
0
0
10
10
10
0
10
0
% N
% Pro:
20
10
30
10
0
0
0
10
20
10
0
10
20
10
0
% P
% Gln:
20
0
0
0
0
0
10
0
0
0
0
0
20
20
20
% Q
% Arg:
20
0
0
10
0
10
10
0
0
0
30
0
0
0
0
% R
% Ser:
0
0
10
20
40
30
0
20
30
20
0
60
20
0
10
% S
% Thr:
10
40
0
30
10
30
0
30
20
0
0
0
10
0
0
% T
% Val:
0
10
0
0
10
0
10
0
0
0
10
10
10
30
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
10
0
0
0
0
0
10
30
0
0
0
30
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _